With the progression of the disease, the process may spread to the palate, gums, palatine tonsils, larynx, and digestive tract. It is important to distinguish weakened individuals, individuals with immunodeficiency conditions who were on long-term use of antibacterial agents, corticosteroids and antineoplastic drugs. The persistence and recurrent nature of such inflammatory lesions requires not only the usual hygienic measures for the care of the oral cavity and teeth, but also appropriate justified therapy aimed at stimulating the protective forces of the oral mucosa.